When debug is set to true, the following happens in the application scope.
1) Batch optimizations will be disabled and hence the compilation of pages takes longer
2) Some additional debug paths get enabled which causes for slower execution of code
3) More memory is used within the application at runtime
4) Scripts and images downloaded from the WebResources.axd handler are not cached
All client-javascript libraries and static images that are deployed via WebResources.axd will be continually downloaded by clients on each page view request and not cached locally within the browser.
When is set, the WebResource.axd handler will automatically set a long cache policy on resources retrieved via it – so that the resource is only downloaded once to the client and cached there forever
When
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